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Paul, the second surgeon has taught me how to live with this awful necrosis. Under no circumstances should you take Forteo.I took Forteo! Question is, is it inflamed or is it dying? He told me that this damnable disease has the potential to take out the entire skull. He reconstructed a mandible out of metal for her. He said on the 1-10 scale, he put me at a 6.5.the worst case he had seen resulted in the patient losing the entire mandible. Once you have had osteonecrosis of the jawbone, any invasive mouth procedure can set the necrosis into motion again. You do not recover from osteonecrosis of the goes dormant. Osteinecrosis of the jawbone is a nightmare.I was unhappy with the treatment I had received.so I consulted with an oral maxiofacial surgeon in a much larger community.what he told me stopped me cold. in the end, I lost my teeth and the right side of my mandible. Go see the oral maxiofacial surgeon for treatment.Ģ014 I developed a massive oral infection that began on a Wednesday evening after Thursday morning I was at the dental office waiting for them to open.one look and I was rushed in.put on antibiotics, xrays, pain killers, and given an appointment for first thing Saturday morning with the visiting oral maxiofacial surgeon.I never slept from Wednesday, nor Thursday, nor Friday.I ate every painkiller I was given, I packed by distorted face with ice, and I sat in bed with the tears rolling. several 28-day sample injectors each month, and if I got there right after the drug salesgirl left her samples, I didn't have to argue with the insurance company that month. It was new back then, and expensive, and I had trouble getting insurance to remember they had agreed to pay for it, but the manufacturer would give my Dr. I did use it myself a number of years ago.
No, I have no financial incentive for recommending it.
Again, my suggestion would be to consult with an endocrinologist who uses Forteo. Osteoporosis is not just the risk of broken bones, but can result in a number of painful conditions, can hasten reduction in your height, and can prevent (spinal or other) fusion surgeries from "taking".
You should consider the bisphosphonates to be an avenue never again travelled, but still need to treat the osteoporosis. I presume you have stopped the bisphosphonate treatment. I definitely would not start out blindly assuming that surgery is the only treatment and must be done immediately, as some foreign dental sites have suggested. If it was me, I would have my internist and dentist line up an endocrinologist who is comfortable working in collaboration with dentists, or who already works with one. Ould not be harmful to attempt treatment with Forteo, if there is any possibility of it being helpful to even part of your mandible Still, if your MRONJ isn't too advanced, Forteo might even obviate the need for surgery to remove bad bone. Still, if the e considered, when possible, It is supposedly possible for bone to be all- but dead or pseudonecrotic, but I like to be skeptical. The small boost in osteoblast activity tilt the bone activity balance just enough to slowly cause new healthy bone to be added at a rate just slightly above that of the osteoclasts which function normally, removing old bone at the proper time to be removed, something that does not happen with bisphosphonates.įorteo has been used very successfully in ther treatment of osteoporosis without the morbidity associated with bisphosphonate drugs. (that is what is meant by "low duty cycle"
It very briefly supplements the activity of the hormone produced by one's own parathyroid glands with essentially normal parathyroid activity for the rest of the day. The drug is self administered once daily via a tiny pinprick-like injection into a fold of skin. By "pulsed", I mean application with a low duty cycle. It was learned in the late 20'th century that slowly pulsed delivery of parathyroid hormone causes osteoblasts to become very slightly more active than their osteoclast counterparts. Forteo is a synthesized human parathyroid hormone. Interference with the activity of osteoclasts has a result of increasing bone density, but at a price: the bone gets sicker and sicker as it's not being replaced by healthy bone.Įnter Forteo. osteoclasts are there for the purpose of removing bad bone to make way for new healthy bone to be laid down by osteoblasts. Have you considered Forteo? It's the antithesis of bisphosphonates.īisphosphonates mess with the quality of bone by reducing the activity of osteoclasts.
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